According to research by The Nation, over the past 20 years, serious and life-threatening adverse reactions, as well as deaths, have been linked to ceftriaxone injection, a component of the medicine used to treat the late musician Mohbad.
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Idowu Owohunwa, the commissioner of police for Lagos, stated in a preliminary report of an ongoing investigation into the death of Ilerioluwa Oladimeji Aloba aka MohBad that one of the late musician’s friends, Ayobami Sadiq (Spending), had called his own nurse, Ms. Feyisayo Ogedengbe, who treated Mohbad with 1 Pack of Ceftriaxone injection; 1
Police chief: “Ms. Feyisayo administered the Tetanus Toxoid on MohBad’s arm and administered the Paracetamol and Ceftriaxone injections intravenously. Ms. Feyisayo confirmed that MohBad immediately began vomiting and developed goose bumps all over his body and face after receiving the Ceftriaxone injection.
The National Agency for Food and Drug Administration and Control (NAFDAC) strongly states in a 7-page publication on the use of “Ceftriaxone 1g powder for solution for injection/infusion” that “Consideration should be given to official guidelines on the appropriate use of antibacterial agents.”
Checks reveal that the Food and Drug Administration (FDA) of the United States imitated Canadian health authorities on January 6, 2012, by outlawing the use of specific Ceftriaxone variants in treating animals and chickens, citing “declines in the prevalence of cephalosporin-resistant Salmonella Heidelberg isolates in chicken meat and in humans.”
The National Centre for Biotechnology in the United States has published a number of papers and drug reviews online. Information that improves science and health by giving access to biological and genomic data reflects long-standing, serious issues that are primarily the result of Ceftriaxone’s simple mismanagement.
Ceftriaxone has a significant tendency for misuse due to its high rate of utilisation, according to one review titled “Evaluation of the Clinical Use of Ceftriaxone among In-Patients in Selected Health Facilities in Uganda,” published on June 25, 2021.
Using the World Health Organization’s (WHO) Drug Use Evaluation indicators, we reviewed a systematic sample of 885 patients’ treatment records that were chosen over a three (3)-month period with the goal of determining the appropriateness of the clinical use of ceftriaxone in nine health facilities in Uganda.
Ceftriaxone, like the majority of cephalosporins, is frequently prescribed inappropriately since it is used in large doses in clinical practise and is available without a prescription in many nations, including Uganda.
According to the report, improper use of antibiotics like ceftriaxone can cause death, raise treatment costs, have an adverse effect on productivity, hasten the emergence of antimicrobial resistance, and expose patients to needless side effects.
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The ability of Ceftriaxone to kill some significant respiratory tract infection-causing bacteria, such as Haemophilus influenzae, Streptococcus pneumoniae, and Klebsiella pneumonia, as well as some strains of the dangerous hospital infection bug Pseudomonas aeruginosa, is one of the drug’s acknowledged benefits.
Ceftriaxone can bind with calcium ions to produce a poorly soluble ceftriaxone-calcium salt that forms precipitates in the urinary tract, also known as urolithiasis [2]. Although its incidence is relatively rare, ceftriaxone-induced urolithiasis could result in severe complications, such as acute kidney injury (AKI), according to another review.
Another study from as far back as August 2012, titled “Adverse events induced by ceftriaxone: a 10-year review of reported cases to Iranian Pharmacovigilance Centre,” demonstrated that research carried out in Iran indicated the necessity for extreme caution and professional guidance when using the medication.
“Our database’s largest number of fatalities (49 cases) was caused by ceftriaxone. 1205 (58%) of the 20,877 reports on ceftriaxone were connected to it, and 357 (30%) of those reports were classified as serious, including cardiac arrest and anaphylactic and anaphylactoid responses.
“Development of preventive methods for minimising those adverse events is required due to the high number of serious cases. One of the risk factors for adverse outcomes is drug usage that is not prescribed (29%).
Rapid intravenous injection of ceftriaxone is another risk factor, according to analysis of the 1030 intravenous administrations of the medication. 116 individuals (9.6%) had previously experienced an adverse reaction to either penicillin, ceftriaxone, or both.
If a patient has a history of allergic reaction to cephalosporins, penicillins, or other beta-lactam antibiotics, we advise using an alternative antibiotic if at all possible.
It was advised that “Severe and life-threatening adverse reactions induced by ceftriaxone are of great concern” in the section titled “What is new and conclusion.” Risk factors that should be avoided include quick intravenous administration, unapproved uses, and patient histories of allergic responses to cephalosporins or penicillins.
(NATION)
